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( A,B ) Representative immunofluorescence images <t>of</t> <t>paxillin</t> and F-actin (phalloidin) ( A ), and <t>pMLC</t> and F-actin (phalloidin) ( B ) immunostains are shown in inverted black and white (ibw) contrast as well as color composites (DAPI signal also included). Scale bar = 10 µm. ( C ) Compared to WT cells (n=243), lamella size is significantly increased in DLC1 KD cells (n=290, p-adjusted<0.001) and DLC1 KO cells (n=242, p-adjusted<0.001), while DLC1 rescue cells (n=57) show significantly lower lamella sizes than both WT (p-adjusted=0.0098) and KO cells (p-adjusted<0.001). ( D ) DLC1 KD cells (n=290) display a significant increase in the total area of focal adhesions per cell (p-adjusted<0.001) compared to WT cells (n=243), while DLC1 KO cells (n=242) do not show a significant difference (p-adjusted=0.09). Rescue cells show a significant decrease in the total area of focal adhesions (p-adjusted<0.001). ANOVA plus Tukey’s honestly significant difference test.
Pmlc, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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( A,B ) Representative immunofluorescence images <t>of</t> <t>paxillin</t> and F-actin (phalloidin) ( A ), and <t>pMLC</t> and F-actin (phalloidin) ( B ) immunostains are shown in inverted black and white (ibw) contrast as well as color composites (DAPI signal also included). Scale bar = 10 µm. ( C ) Compared to WT cells (n=243), lamella size is significantly increased in DLC1 KD cells (n=290, p-adjusted<0.001) and DLC1 KO cells (n=242, p-adjusted<0.001), while DLC1 rescue cells (n=57) show significantly lower lamella sizes than both WT (p-adjusted=0.0098) and KO cells (p-adjusted<0.001). ( D ) DLC1 KD cells (n=290) display a significant increase in the total area of focal adhesions per cell (p-adjusted<0.001) compared to WT cells (n=243), while DLC1 KO cells (n=242) do not show a significant difference (p-adjusted=0.09). Rescue cells show a significant decrease in the total area of focal adhesions (p-adjusted<0.001). ANOVA plus Tukey’s honestly significant difference test.
Anti Pmlc, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti pmlc/product/Cell Signaling Technology Inc
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pmlc cell signaling technology  (Cell Signaling Technology Inc)
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( A,B ) Representative immunofluorescence images <t>of</t> <t>paxillin</t> and F-actin (phalloidin) ( A ), and <t>pMLC</t> and F-actin (phalloidin) ( B ) immunostains are shown in inverted black and white (ibw) contrast as well as color composites (DAPI signal also included). Scale bar = 10 µm. ( C ) Compared to WT cells (n=243), lamella size is significantly increased in DLC1 KD cells (n=290, p-adjusted<0.001) and DLC1 KO cells (n=242, p-adjusted<0.001), while DLC1 rescue cells (n=57) show significantly lower lamella sizes than both WT (p-adjusted=0.0098) and KO cells (p-adjusted<0.001). ( D ) DLC1 KD cells (n=290) display a significant increase in the total area of focal adhesions per cell (p-adjusted<0.001) compared to WT cells (n=243), while DLC1 KO cells (n=242) do not show a significant difference (p-adjusted=0.09). Rescue cells show a significant decrease in the total area of focal adhesions (p-adjusted<0.001). ANOVA plus Tukey’s honestly significant difference test.
Pmlc Cell Signaling Technology, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phosphor myosin light chain pmlc  (Cell Signaling Technology Inc)
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( A,B ) Representative immunofluorescence images <t>of</t> <t>paxillin</t> and F-actin (phalloidin) ( A ), and <t>pMLC</t> and F-actin (phalloidin) ( B ) immunostains are shown in inverted black and white (ibw) contrast as well as color composites (DAPI signal also included). Scale bar = 10 µm. ( C ) Compared to WT cells (n=243), lamella size is significantly increased in DLC1 KD cells (n=290, p-adjusted<0.001) and DLC1 KO cells (n=242, p-adjusted<0.001), while DLC1 rescue cells (n=57) show significantly lower lamella sizes than both WT (p-adjusted=0.0098) and KO cells (p-adjusted<0.001). ( D ) DLC1 KD cells (n=290) display a significant increase in the total area of focal adhesions per cell (p-adjusted<0.001) compared to WT cells (n=243), while DLC1 KO cells (n=242) do not show a significant difference (p-adjusted=0.09). Rescue cells show a significant decrease in the total area of focal adhesions (p-adjusted<0.001). ANOVA plus Tukey’s honestly significant difference test.
Phosphor Myosin Light Chain Pmlc, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pmlc antibody cat 3674s  (Cell Signaling Technology Inc)
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( A,B ) Representative immunofluorescence images <t>of</t> <t>paxillin</t> and F-actin (phalloidin) ( A ), and <t>pMLC</t> and F-actin (phalloidin) ( B ) immunostains are shown in inverted black and white (ibw) contrast as well as color composites (DAPI signal also included). Scale bar = 10 µm. ( C ) Compared to WT cells (n=243), lamella size is significantly increased in DLC1 KD cells (n=290, p-adjusted<0.001) and DLC1 KO cells (n=242, p-adjusted<0.001), while DLC1 rescue cells (n=57) show significantly lower lamella sizes than both WT (p-adjusted=0.0098) and KO cells (p-adjusted<0.001). ( D ) DLC1 KD cells (n=290) display a significant increase in the total area of focal adhesions per cell (p-adjusted<0.001) compared to WT cells (n=243), while DLC1 KO cells (n=242) do not show a significant difference (p-adjusted=0.09). Rescue cells show a significant decrease in the total area of focal adhesions (p-adjusted<0.001). ANOVA plus Tukey’s honestly significant difference test.
Pmlc Antibody Cat 3674s, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pmlc antibody cat 3674s/product/Cell Signaling Technology Inc
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( A,B ) Representative immunofluorescence images of paxillin and F-actin (phalloidin) ( A ), and pMLC and F-actin (phalloidin) ( B ) immunostains are shown in inverted black and white (ibw) contrast as well as color composites (DAPI signal also included). Scale bar = 10 µm. ( C ) Compared to WT cells (n=243), lamella size is significantly increased in DLC1 KD cells (n=290, p-adjusted<0.001) and DLC1 KO cells (n=242, p-adjusted<0.001), while DLC1 rescue cells (n=57) show significantly lower lamella sizes than both WT (p-adjusted=0.0098) and KO cells (p-adjusted<0.001). ( D ) DLC1 KD cells (n=290) display a significant increase in the total area of focal adhesions per cell (p-adjusted<0.001) compared to WT cells (n=243), while DLC1 KO cells (n=242) do not show a significant difference (p-adjusted=0.09). Rescue cells show a significant decrease in the total area of focal adhesions (p-adjusted<0.001). ANOVA plus Tukey’s honestly significant difference test.

Journal: eLife

Article Title: GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling

doi: 10.7554/eLife.90305

Figure Lengend Snippet: ( A,B ) Representative immunofluorescence images of paxillin and F-actin (phalloidin) ( A ), and pMLC and F-actin (phalloidin) ( B ) immunostains are shown in inverted black and white (ibw) contrast as well as color composites (DAPI signal also included). Scale bar = 10 µm. ( C ) Compared to WT cells (n=243), lamella size is significantly increased in DLC1 KD cells (n=290, p-adjusted<0.001) and DLC1 KO cells (n=242, p-adjusted<0.001), while DLC1 rescue cells (n=57) show significantly lower lamella sizes than both WT (p-adjusted=0.0098) and KO cells (p-adjusted<0.001). ( D ) DLC1 KD cells (n=290) display a significant increase in the total area of focal adhesions per cell (p-adjusted<0.001) compared to WT cells (n=243), while DLC1 KO cells (n=242) do not show a significant difference (p-adjusted=0.09). Rescue cells show a significant decrease in the total area of focal adhesions (p-adjusted<0.001). ANOVA plus Tukey’s honestly significant difference test.

Article Snippet: Cells were incubated overnight with the primary antibody 1:250 dilution for paxillin (Abcam ab32084), 1:50 for pMLC (Cell Signaling Antibody #3671).

Techniques: Immunofluorescence